We have been using NetSuite for over 3 years now.  We used to have several applications including QuickBooks Enterprise, ACT, MIVA eCommerce, ShipGear and others.  It was difficult managing all the applications and interfaces.  We now have a single application for our ERP, CRM and eCommerce.  The front to back end integration and 360 degree view of our customers are awesome.  I cannot imagine running our business without NetSuite. 

Stephen @ http://www.possupply.com